Concept
Nucleoid
Related publications (67)
Chromosome organization shapes replisome dynamics in Caulobacter crescentus
Suliana Manley, Chen Zhang, Laurent Casini
DNA replication in bacteria takes place on highly compacted chromosomes, where segregation, transcription, and repair must occur simultaneously. Within this dynamic environment, colocalization of sister replisomes has been observed in many bacterial specie ...
Nature Portfolio2024Archaeal type IV pili stabilize Haloferax volcanii biofilms in flow
Alexandre Louis André Persat, Lorenzo Anton-Louis Talà, Pascal Damian Odermatt
Multicellular communities of contiguous cells attached to solid surfaces called biofilms represent a common microbial strategy to improve resilience in adverse environments.1-3 While bacterial biofilms have been under intense investigation, whether archaea ...
Cambridge2023Anaerobic arsenic methylation as a microbial warfare strategy
Rizlan Bernier-Latmani, Karin Lederballe Meibom, Nicolas Louis Maurice Jacquemin, Hugo Sallet, Jiangtao Qiao
Microbial arsenic methylation is established as a detoxification process under aerobic conditions (converting arsenite to monomethylated arsenate) but proposed to be a microbial warfare strategy under anoxic conditions due to the toxicity of its main produ ...
2023Systematic inference and comparison of multi-scale chromatin sub-compartments connects spatial organization to cell phenotypes
Elisa Oricchio, Daniele Tavernari, Stephanie Jocelyne Sungalee, Giovanni Ciriello, Marco Mina
Chromatin compartmentalization reflects biological activity. However, inference of chromatin sub-compartments and compartment domains from chromosome conformation capture (Hi-C) experiments is limited by data resolution. As a result, these have been charac ...
NATURE RESEARCH2021Applying Peptide and Protein Synthesis to Study Post-translational Modifications in Epigenetics and Beyond
Epigenetics research focuses on the study of heritable gene regulatory mechanisms that do not involve changes of the DNA sequence. Such mechanisms include post-translational modifications of histone proteins that organize the genome in the nucleus into a n ...
SWISS CHEMICAL SOC2021Development of Covalent Chitosan-Polyethylenimine Derivatives as Gene Delivery Vehicle: Synthesis, Characterization, and Evaluation
Sandrine Gerber, Céline Marie Anne Journot, Laura Camille Louise Nicolle
There is an increasing interest in cationic polymers as important constituents of non-viral gene delivery vectors. In the present study, we developed a versatile synthetic route for the production of covalent polymeric conjugates consisting of water-solubl ...
2021Structural transitions and mechanochemical coupling in the nucleoprotein filament explain homology selectivity and Rad51 protein cooperativity in cellular DNA repair
The nucleoprotein filament (NPF) is the fundamental element of homologous recombination (HR), a major mechanism for the repair of double-strand DNA breaks in the cell. The NPF is made of the damaged DNA strand surrounded by recombinase proteins, and its se ...
AMER PHYSICAL SOC2020DNA-segment-capture model for loop extrusion by structural maintenance of chromosome (SMC) protein complexes
Paolo De Los Rios, Alessandro Barducci
Cells possess remarkable control of the folding and entanglement topology of long and flexible chromosomal DNA molecules. It is thought that structural maintenance of chromosome (SMC) protein complexes play a crucial role in this, by organizing long DNAs i ...
2019An extended regulatory landscape drives Tbx18 activity in a variety of prostate-associated cell lineages
Christopher Chase Bolt, Soumya Negi
The evolutionarily conserved transcription factor, Tbx18, is expressed in a dynamic pattern throughout embryonic and early postnatal life and plays crucial roles in the development of multiple organ systems. Previous studies have indicated that this dynami ...
ACADEMIC PRESS INC ELSEVIER SCIENCE2019Chromatin Fiber Invasion and Nucleosome Displacement by the Rap1 Transcription Factor
Rudolf Hovius, Beat Fierz, Iuliia Boichenko, Maxime Nicolas Mivelaz, Anne-Marinette Thi Phuong Hanh Cao
Pioneer transcription factors (pTFs) bind to target sites within compact chromatin, initiating chromatin remodeling and controlling the recruitment of downstream factors. The mechanisms by which pTFs overcome the chromatin barrier are not well understood. ...
2019