Concept

Retinal detachment

Related publications (110)

Differential regulation of Dlg1, Scrib, and Lgl1 expression in a transgenic mouse model of ocular cancer

Purpose: Discs large (dlg), scribble (scrib), and lethal giant larvae (lgl) are major suppressor genes in Drosophila melanogaster. They encode proteins that regulate cell polarity and cell proliferation in Drosophila and mammals. However, their basic oncog ...

2008

Regulation of Prenatal Human Retinal Neurosphere Growth and Cell Fate Potential by Retinal Pigment Epithelium and Mash1

Bernard Schneider

During development of the central nervous system, stem and progenitor cell proliferation and differentiation are controlled by complex inter- and intracellular interactions that orchestrate the precise spatiotemporal production of particular cell types. Wi ...

2008

ETS-1 and ETS-2 are upregulated in a transgenic mouse model of pigmented ocular neoplasm

Friedrich Beermann

Purpose: Choroidal melanoma is the most common primary malignant ocular tumor in human adults. Relevant mouse models of human uveal melanoma still remain to be developed. We have studied the transgenic mouse strain, Tyrp-1-TAg, to try to gain insight into ...

2008

MAP kinase pathways in UV-induced apoptosis of retinal pigment epithelium ARPE19 cells

The retinal pigment epithelium (RPE) is constantly exposed to external injuries which lead to degeneration, dysfunction or loss of RPE cells. The balance between RPE cells death and proliferation may be responsible for several diseases of the underlying re ...

2008

Modelling and microfabrication of a polyimide-based 3D tissue coupled electrodes for electrical stimulation in the chick retina

Philippe Renaud, Sri Harsha Kasi Raj

We present a new flexible microfabricated polyimide-based platinum array of 3D “tissue coupled electrodes” (TCEs) applied for local stimulation of the chick retinal photoreceptor layer and simultaneous patch clamp recording from a single retinal ganglion c ...

2008

The Notch pathway: hair graying and pigment cell homeostasis

Friedrich Beermann, Karine Schouwey

The Notch signaling pathway is an essential cell-cell interaction mechanism, which regulates processes such as cell proliferation, cell fate decisions, differentiation or stem cell maintenance. Pigmentation in mammals is provided by melanocytes, which are ...

2008

Vectorial reconstruction of retinal blood flow in three dimensions measured with high resolution resonant Doppler Fourier domain optical coherence tomography

Theo Lasser, Rainer Leitgeb, Martin Villiger, Adrian Bachmann, Roland Michaely, Cédric Blatter

Resonant Doppler Fourier domain optical coherence tomography (FDOCT) is a functional imaging tool for extracting tissue flow. The method is based on the effect of interference fringe blurring in spectrometer-based FDOCT, where the path difference between s ...

2007

Vectorial retinal blood flow and optical vessel vivisection for 3D angiography with high resolution resonant Doppler OCT

Theo Lasser, Rainer Leitgeb, Martin Villiger, Adrian Bachmann, Roland Michaely, Cédric Blatter

PURPOSE: To perform high speed and completely non-invasive 3D angiography at the optic nerve head region and to reconstruct vectorial 3D blood flow from optically segmented blood vessel structure as a pre-requisite for testing retinal function and physiolo ...

2007

Measurement of retinal physiology using functional Fourier domain OCT concepts

Theo Lasser, Christophe Pache, Rainer Leitgeb, Martin Villiger, Adrian Bachmann, Roland Michaely, Cédric Blatter

Fourier Domain OCT proved to be an outstanding tool for measuring 3D retinal structures with high sensitivity, resolution, and speed. We extended the FDOCT concept towards functional imaging by analyzing the spectroscopic tissue properties, polarization co ...

SPIE2007

Phase-locked Fourier domain optical coherence tomography

Fourier or spectral domain optical coherence tomography (FDOCT) is a multi-dimensional interferometric imaging modality that has attracted increasing interest during the last few years. The reason is its outstanding sensitivity allowing high speed 2D and 3 ...

EPFL2007

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