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Preterm premature rupture of the foetal membranes (fruber vorzeitiger Blasensprung) has remained a devastating complication of pregnancy with very high risk of pregnancy loss. Several methods of sealing spontaneously ruptured membranes to stop amniotic flu ...
We developed an ex vivo gene therapy approach for the regulated delivery of therapeutic proteins based on the implantation of encapsulated, genetically engineered C(2)C(12) myoblasts. We investigated doxycycline-based regulation of gene expression to modul ...
The cognitive deficits observed in children with cyanotic congenital heart disease suggest involvement of the developing hippocampus. Chronic postnatal hypoxia present during infancy in these children may play a role in these impairments. To understand the ...
In this paper, we intend to gain an understanding of the interaction of light with microstructures. Measurements of amplitude and phase in the diffracted field close to gratings using a heterodyne scanning probe are presented. Coherent light diffracted by ...
Arterial structure plays an important role in drug delivery from intraarterial depots. The internal elastic lamina forms a major diffusive resistance to the transport of macromol. drugs from intimally-adherent hydrogel depots to the arterial media. The obj ...
Degeneration of the intervertebral disc (IVD) is thought to be one main factor in the development of back pain. It is not a symptom by itself but can lead to painful pathological conditions. Current treatments aim at relieving pain by conservative care, me ...
Motivation. The study of human brain development in its early stage is today possible thanks to in vivo fetal magnetic resonance imaging (MRI) techniques. A quantitative analysis of fetal cortical surface represents a new approach which can be used as a ma ...
For tissue engineering, several cell types and tissues have been proposed as starting material. Allogenic skin products available for therapeutic usage are mostly developed with cell culture and with foreskin tissue of young individuals. Fetal skin cells o ...
Tackling neurodegenerative diseases represents a formidable challenge for our ageing society. Recently, major achievements have been made in understanding the molecular mechanisms responsible for such diseases, and, simultaneously, numerous proteins such a ...
