The Indo-Parthian Kingdom was a Parthian kingdom founded by Gondophares, and active from 19 CE to c. 226 CE. At their zenith, they ruled an area covering parts of eastern Iran, various parts of Afghanistan and the northwest regions of the Indian subcontinent (most of modern Pakistan and parts of northwestern India). The rulers may have been members of the House of Suren, and the kingdom has even been called the "Suren Kingdom" by some authors.
The kingdom was founded in 19/20 when the governor of Drangiana (Sakastan) Gondophares declared independence from the Parthian Empire. He would later make expeditions to the east, conquering territory from the Indo-Scythians and Indo-Greeks, thus transforming his kingdom into an empire. The domains of the Indo-Parthians were greatly reduced following the invasions of the Kushans in the second half of the 1st. century. They managed to retain control of Sakastan, until its conquest by the Sasanian Empire in c. 224/5. In Baluchistan, the Paratarajas, a local Indo-Parthian dynasty, fell into the orbit of the Sasanian Empire circa 262 CE.
The Indo-Parthians are noted for the construction of the Buddhist monastery Takht-i-Bahi (UNESCO World Heritage Site) in Mardan, Pakistan.
Gondophares I originally seems to have been a ruler of Seistan in what is today eastern Iran, probably a vassal or relative of the Apracarajas. He may have replaced previous Parthian governors of Seistan, such as Cheiroukes or Tanlismaidates. These Parthian satraps had been ruling the region of Sakastan since the time when Mithridates II (124–88 BC) had vanquished the Sakas of the region.
Around 20–10 BC, he made conquests in the former Indo-Scythian kingdom, perhaps after the death of the important ruler Azes. Gondophares became the ruler of areas comprising Arachosia, Seistan, Sindh, Punjab, and the Kabul valley, but it does not seem as though he held territory beyond eastern Punjab.