Concept

Mutant

Related publications (34)

Dynamic Reorganization of Extremely Long-Range Promoter-Promoter Interactions between Two States of Pluripotency

Serum-to-2i interconversion of mouse embryonic stem cells (mESCs) is a valuable in vitro model for early embryonic development. To assess whether 3D chromatin organization changes during this transition, we established Capture Hi-C with target-sequence enr ...

Cell Press2015

Characterisation of ypa1 and ypa2, the Schizosaccharomyces pombe orthologues of the peptidyl proyl isomerases that activate PP2A, reveals a role for Ypa2p in the regulation of cytokinesis

Viesturs Simanis, Anupama Goyal

The Schizosaccharomyces pombe septation initiation network regulates cytokinesis. Cdc7p is the first kinase in the core septation initiation network; we have screened genetically for SIN regulators by isolating cold-sensitive suppressors of cdc7-24. Our sc ...

2012

Isolation and Characterisation of Regulators of the Septation Initiation Network Regulators in Fission Yeast

Anupama Goyal

The septation initiation network (SIN) in Schizosaccharomyces pombe regulates cytokinesis. Cdc7p encodes the first kinase in the core SIN pathway. In this study, I performed a genetic screen to identify novel regulators of the SIN pathway by isolating spon ...

EPFL2012

Topology and Dynamics of the Zebrafish Segmentation Clock Core Circuit

Bart Deplancke, Andrew Charles Oates, Sebastian Maerkl, Daniele Soroldoni, Alina Isakova

During vertebrate embryogenesis, the rhythmic and sequential segmentation of the body axis is regulated by an oscillating genetic network termed the segmentation clock. We describe a new dynamic model for the core pace-making circuit of the zebrafish segme ...

Public Library Science2012

Topology and dynamics of the zebrafish segmentation clock core circuit

Bart Deplancke, Andrew Charles Oates, Sebastian Maerkl, Daniele Soroldoni, Alina Isakova

2012

Single-Cell Analysis of Mycobacterial Persistence Using Microfabricated Tools

Meltem Elitas

Bacterial cells behave as individuals despite being genetically identical and subject to the same environment. Although the underlying mechanisms of cellular individuality are not well understood, temporal variation of gene expression and protein levels in ...

EPFL2012

Tissue micromanipulation in zebrafish embryos

Andrew Charles Oates

Although a common approach in large vertebrate embryos such as chick or frog, manipulation at the tissue level is only rarely applied to zebrafish embryos. Despite its relatively small size, the zebrafish embryo can be readily used for micromanipulations s ...

2009

Rapid Classification of Phenotypic Mutants of Arabidopsis via Metabolite Fingerprinting

Anthony Christopher Davison, Vahid Partovi Nia

We evaluated the application of gas chromatography-mass spectrometry metabolic fingerprinting to classify forward genetic mutants with similar phenotypes. Mutations affecting distinct metabolic or signaling pathways can result in common phenotypic traits t ...

2007

Tel1 kinase and subtelomere-bound Tbf1 mediate preferential elongation of short telomeres by telomerase in yeast

Joachim Lingner

Telomerase enables telomere length homeostasis, exhibiting increasing preference for telomeres as their lengths decline. This regulation involves telomere repeat-bound Rap1, which provides a length-dependent negative feedback mechanism, and the Tel1 and Me ...

2007

Inactivation of Rv2525c, a substrate of the twin arginine translocation (Tat) system of Mycobacterium tuberculosis, increases beta-lactam susceptibility and virulence

Stewart Cole

The twin arginine translocation (Tat) system is used by many bacteria to export fully folded proteins containing cofactors. Here, we show genetically that this system is essential for Mycobacterium tuberculosis, as the tatAC operon and tatB genes could be ...

2006

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