Concept

Essential hypertension

Related publications (50)

The "systolic volume balance" method for the noninvasive estimation of cardiac output based on pressure wave analysis

Nikolaos Stergiopoulos, Orestis Vardoulis

Papaioannou TG, Vardoulis O, Stergiopulos N. The "systolic volume balance" method for the noninvasive estimation of cardiac output based on pressure wave analysis. Am J Physiol Heart Circ Physiol 302: H2064-H2073, 2012. First published March 16, 2012; doi: ...

2012

Pressure and Flow Wave Propagation in Patient-Specific Models of the Arterial Tree

Philippe Reymond

Blood flow in the arterial circulation induces hemodynamic forces that play an important role in various forms of vascular diseases. Temporal variation of the wall shear stress seems to play a significant role in atherogenesis and plaque stability. Flow in ...

EPFL2011

Cardiovascular effects of arginase inhibition in spontaneously hypertensive rats with fully developed hypertension

Nikolaos Stergiopoulos, Rafaela Fernandes Da Silva

Growing evidence suggests that arginase misregulation plays a key role in the pathophysiology of essential hypertension. In the present study, we investigated the potential cardiovascular therapeutic effects of a long-term treatment with an arginase inhibi ...

Oxford University Press2010

A structure-based model of arterial remodeling in response to sustained hypertension

Nikolaos Stergiopoulos, Alkiviadis Tsamis, Alexander Rachev

A novel structure-based mathematical model of arterial remodeling in response to a sustained increase in pressure is proposed. The model includes two major aspects of remodeling in a healthy matured vessel. First, the deviation of the wall stress and flow- ...

2009

Three- and four-element Windkessel models: assessment of their fitting performance in a large cohort of healthy middle-aged individuals

Nikolaos Stergiopoulos, Patrick Segers, Nico Westerhof

Lumped-parameter models are used to estimate the global arterial properties by fitting the model to measured (aortic) pressure and flow. Different model configurations coexist, and it is still an open question as to which model optimally reflects the arter ...

2008

Effects of an aging vascular model on healthy and diseased hearts

Nikolaos Stergiopoulos, Rafaela Fernandes Da Silva, David Jegger, Patrick Segers

The vitamin D(3) and nicotine (VDN) model is a model of isolated systolic hypertension (ISH) due to arterial calcification raising arterial stiffness and vascular impedance similar to an aged and stiffened arterial tree. We therefore analyzed the impact of ...

2007

Effects of a stiffened arterial tree on ventricular-arterial coupling in healthy and diseased hearts

David Jegger

In this thesis we study ventricular-arterial coupling in rodents under the influence of arterial stiffening and myocardial infarction (MI), combination of the two considered as a novel cardiovascular research model for diseased hearts pumping against an ag ...

EPFL2006

Shear stress and cyclic circumferential stretch, but not pressure, alter connexin43 expression in endothelial cells

Nikolaos Stergiopoulos, Paolo Silacci

Hemodynamic forces play a critical role in atherogenesis, as evidenced by the focal pattern of development of atherosclerotic lesions. Whereas disturbed flow in the branches and curved regions of large arteries is proatherogenic, laminar flow in the straig ...

2006

Arterial in vitro remodeling

Gabriela Montorzi Thorell

Vascular remodeling is defined as any enduring change in the size and composition of an adult blood vessel, allowing adaptation or repair. The vascular remodeling response has been shown to depend on a variety of endogenous and environmental factors. Physi ...

EPFL2004

Geometrical, functional, and histomorphometric adaptation of rat carotid artery in induced hypertension

Nikolaos Stergiopoulos, Martin Zulliger

Acute and long-term (up to 56 days) evolution of geometry, structural properties, vascular smooth muscle (VSM) tone and histomorphometric properties of the rat common carotid arteries under induced hypertension were investigated. Hypertension was induced i ...

2003

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