Concept

Atherosclerosis

Related publications (164)

Comparative assessment of intimal hyperplasia development after 14 days in two different experimental settings: tissue culture versus ex vivo continuous perfusion of human saphenous vein

Intimal hyperplasia (IH) is a vascular remodeling process which often leads to failure of arterial bypass or hemodialysis access. Experimental and clinical work have provided insight in IH development; however, further studies under precise controlled cond ...

2004

PPAR agonists in the treatment of atherosclerosis

Johan Auwerx

Current treatment for atherosclerotic heart disease consists mainly of the administration of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors or 'statin' class of drugs. Statins, which lower low-density lipoprotein cholesterol levels an ...

2003

PPAR-alpha effects on the heart and other vascular tissues

Johan Auwerx

Peroxisome proliferator-activated receptor (PPAR)-alpha is a member of a large nuclear receptor superfamily whose main role is to activate genes involved in fatty acid oxidation in the liver, heart, kidney, and skeletal muscle. While currently used mainly ...

2003

Modelling the electrophysiological endothelial cell response to bradykinin

Jean-Jacques Meister, Jean-Louis Bény, Alexander Schuster

The goal of the present study is to construct a biophysical model of the coronary artery endothelial cell response to bradykinin. This model takes into account intracellular Ca2+ dynamics, membrane potential, a non-selective cation channel, and two Ca(2+)- ...

Springer-Verlag2003

Oxidized phospholipids inhibit cyclooxygenase-2 in human macrophages via nuclear factor-kappaB/IkappaB- and ERK2-dependent mechanisms

Johan Auwerx

OBJECTIVE: Oxidized low-density lipoproteins (ox-LDL) or their components suppress macrophage inflammatory response by down-regulating cytokine synthesis, nitric oxide synthase and inducible cyclooxygenase (Cox-2). This event is crucial for the pathophysio ...

2002

Liver X receptors: Xcreting Xol to combat atherosclerosis

Johan Auwerx

Liver X receptors (LXRs) are nuclear receptors that act as metabolic sensors for cellular cholesterol (Xol) and oxysterol content. Increased oxysterol levels activate LXRs, which then induce: the removal of cholesterol out of peripheral cells; transport of ...

2002

Activation of the peroxisome proliferator-activated receptor alpha protects against myocardial ischaemic injury and improves endothelial vasodilatation

Johan Auwerx, Kristina Schoonjans

BACKGROUND: The peroxisome proliferator-activated receptor alpha (PPARalpha) plays an important role in the metabolism of lipoproteins and fatty acids, and seems to protect against the development of atherosclerosis. To evaluate the possible protective rol ...

2002

Reduction of atherosclerosis in apolipoprotein E knockout mice by activation of the retinoid X receptor

Johan Auwerx

A common feature of many metabolic pathways is their control by retinoid X receptor (RXR) heterodimers. Dysregulation of such metabolic pathways can lead to the development of atherosclerosis, a disease influenced by both systemic and local factors. Here w ...

2001

Cytosolic-free calcium in smooth-muscle and endothelial cells in an intact arterial wall from rat mesenteric artery in vitro

Nikolaos Stergiopoulos, Jean-Jacques Meister, Jean-Louis Bény, Alexander Schuster

The regulation of cytosolic-free calcium concentration of smooth-muscle and endothelial cells was mainly studied on cultured cells where the cross talk between these two coupled cell types is lost. In the present study, the cytosolic-free calcium concentra ...

Elsevier2001

Computational vascular fluid dynamics: problems, models and methods

Alfio Quarteroni

In the cardiovascular system, morphology and functionality are closely related. Altered flow conditions play an important role in the development of arterial disease. In turn, these flow conditions are modified by arterial wall changes. A detailed understa ...

2000

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