Publications related to DNA repair

DNA-uptake pilus of Vibrio cholerae capable of kin-discriminated auto-aggregation

Melanie Blokesch, Sandrine Stutzmann, Candice Stoudmann, David William Adams

Natural competence for transformation is a widely used and key mode of horizontal gene transfer that can foster rapid bacterial evolution. Competent bacteria take-up DNA from their environment using Type IV pili, a widespread and multi-purpose class of cel ...

2018

EaRL: Toolbox for Earthquake Risk and Loss Assessment of Building Assets

Dimitrios Lignos, Ahmed Mohamed Ahmed Elkady, Seong-Hoon Hwang

Infrastructure (asset) risk management is essential for a resilient environment. Several industries are concerned to improve their building asset preparedness subject to seismic hazard. To this end, the development of software tools that quantify and asses ...

2018

Restriction endonuclease AgeI is a monomer which dimerizes to cleave DNA

Virginija Jovaisaite

Although all Type II restriction endonucleases catalyze phosphodiester bond hydrolysis within or close to their DNA target sites, they form different oligomeric assemblies ranging from monomers, dimers, tetramers to higher order oligomers to generate a dou ...

Oxford University Press (OUP)2017

The telomeric DNA damage response occurs in the absence of chromatin decompaction

Joachim Lingner, Suliana Manley, Kyle Michael Douglass, Verena Pfeiffer, Aleksandra Vancevska

Telomeres are specialized nucleoprotein structures that protect chromosome ends from DNA damage response (DDR) and DNA rearrangements. The telomeric shelterin protein TRF2 suppresses the DDR, and this function has been attributed to its abilities to trigge ...

Cold Spring Harbor Laboratory2017

Cdk2 strengthens the intra-S checkpoint and counteracts cell cycle exit induced by DNA damage

Gérald Joseph Paul Lossaint, Katarina Bacevic

Although cyclin-dependent kinase 2 (Cdk2) controls the G1/S transition and promotes DNA replication, it is dispensable for cell cycle progression due to redundancy with Cdk1. Yet Cdk2 also has non-redundant functions that can be revealed in certain genetic ...

Springer Nature2017

MAR-Mediated transgene integration into permissive chromatin and increased expression by recombination pathway engineering

Christian Iseli, Nicolas Mermod, Thomas Junier, Samuel Neuenschwander, Ioannis Xenarios

Untargeted plasmid integration into mammalian cell genomes remains a poorly understood and inefficient process. The formation of plasmid concatemers and their genomic integration has been ascribed either to non-homologous end-joining (NHEJ) or homologous r ...

2017

Interbacterial predation as a strategy for DNA acquisition in naturally competent bacteria

Melanie Blokesch

Natural competence enables bacteria to take up exogenous DNA. The evolutionary function of natural competence remains controversial, as imported DNA can act as a source of substrates or can be integrated into the genome. Exogenous homologous DNA can also b ...

Nature Publishing Group2017

DNA binding by PHF1 prolongs PRC2 residence time on chromatin and thereby promotes H3K27 methylation

Beat Fierz, Andreas Linus Bachmann

Polycomb repressive complex 2 (PRC2) trimethylates histone H3 at lysine 27 to mark genes for repression. We measured the dynamics of PRC2 binding on recombinant chromatin and free DNA at the single-molecule level using total internal reflection fluorescenc ...

Nature Publishing Group2017

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DNA repair

A Blockchain Consensus Protocol With Horizontal Scalability

DNA-uptake pilus of Vibrio cholerae capable of kin-discriminated auto-aggregation

EaRL: Toolbox for Earthquake Risk and Loss Assessment of Building Assets

Restriction endonuclease AgeI is a monomer which dimerizes to cleave DNA

The telomeric DNA damage response occurs in the absence of chromatin decompaction

Cdk2 strengthens the intra-S checkpoint and counteracts cell cycle exit induced by DNA damage

Gene editing in photoreceptor progenitors prevents visual function loss in a mouse model of retinal degeneration

MAR-Mediated transgene integration into permissive chromatin and increased expression by recombination pathway engineering

Interbacterial predation as a strategy for DNA acquisition in naturally competent bacteria

DNA binding by PHF1 prolongs PRC2 residence time on chromatin and thereby promotes H3K27 methylation

Graph Chatbot

Chat with Graph Search

Gene editing in photoreceptor progenitors prevents visual function loss in a mouse model of retinal degeneration

Interbacterial predation as a strategy for DNA acquisition in naturally competent bacteria

A Blockchain Consensus Protocol With Horizontal Scalability

DNA binding by PHF1 prolongs PRC2 residence time on chromatin and thereby promotes H3K27 methylation

DNA-uptake pilus of Vibrio cholerae capable of kin-discriminated auto-aggregation

MAR-Mediated transgene integration into permissive chromatin and increased expression by recombination pathway engineering

EaRL: Toolbox for Earthquake Risk and Loss Assessment of Building Assets

The telomeric DNA damage response occurs in the absence of chromatin decompaction

Restriction endonuclease AgeI is a monomer which dimerizes to cleave DNA

Cdk2 strengthens the intra-S checkpoint and counteracts cell cycle exit induced by DNA damage