Publications related to Multiple organ dysfunction syndrome

A common NFKB1 variant detected through antibody analysis in UK Biobank predicts risk of infection and allergy

Jacques Fellay, Flavia Aurelia Shoko Hodel

Infectious agents contribute significantly to the global burden of diseases through both acute infection and their chronic sequelae. We leveraged the UK Biobank to identify genetic loci that influence humoral immune response to multiple infections. From 45 ...

Cambridge2024

Host genomics of SARS-CoV-2 infection

Jacques Fellay, Christian Axel Wandall Thorball

SARS-CoV-2 infected a large fraction of humans in the past 2 years. The clinical presentation of acute infection varies greatly between individuals, ranging from asymptomatic or mild to life-threatening COVID-19 pneumonia with multi-organ complications. De ...

SPRINGERNATURE2022

Rapid Progression of Kidney Dysfunction in People Living With HIV: Use of Polygenic and Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) Risk Scores

Jacques Fellay, Christian Axel Wandall Thorball

Background In people with human immunodeficiency virus (PWH), it is unknown whether genetic background associates with rapid progression of kidney dysfunction (ie, estimated glomerular filtration rate [eGFR] decrease of >5mL/min/1.73m(2) per year for >= 3 ...

OXFORD UNIV PRESS INC2021

Disturbed mitochondrial dynamics in CD8(+)TILs reinforce T cell exhaustion

Li Tang, George Coukos, Marcela Rincón-Restrepo, Nicola Vannini, Min Gao, Fabien Franco

Ho and colleagues report that mitochondrial dysfunction and impaired mitophagy triggered by the tumor microenvironment lead to subsequent epigenetic changes and cause permanent T cell exhaustion and dysfunction. The metabolic challenges present in tumors a ...

2020

Comparative RNA-Seq analyses ofDrosophilaplasmatocytes reveal gene specific signatures in response to clean injury and septic injury

Bruno Lemaitre, Jan Paul Dudzic, Elodie Julie Virginie Ramond

Drosophila melanogaster's blood cells (hemocytes) play essential roles in wound healing and are involved in clearing microbial infections. Here, we report the transcriptional changes of larval plasmatocytes after clean injury or infection with the Gram-neg ...

PUBLIC LIBRARY SCIENCE2020

Early sepsis diagnosis via protein and miRNA biomarkers using a novel point-of-care photonic biosensor

Hatice Altug, Alexander Belushkin

y Sepsis is a condition characterized by a severe stage of blood-infection often leading to tissue damage, organ failure and finally death. Fast diagnosis and identification of the sepsis stage (sepsis, severe sepsis or septic shock) is critical for the pa ...

ELSEVIER SCIENCE BV2019

Rapid and Digital Detection of Inflammatory Biomarkers Enabled by a Novel Portable Nanoplasmonic Imager

Hatice Altug, Filiz Yesilköy, Alexander Belushkin

New point-of-care diagnostic devices are urgently needed for rapid and accurate diagnosis, particularly in the management of life-threatening infections and sepsis, where immediate treatment is key. Sepsis is a critical condition caused by systemic respons ...

WILEY-V C H VERLAG GMBH2019

Pathogenic commonalities between spinal muscular atrophy and amyotrophic lateral sclerosis: Converging roads to therapeutic development

Bernard Schneider

Spinal muscular atrophy (SMA) and amyotrophic lateral sclerosis (ALS) are the two most common motoneuron disorders, which share typical pathological hallmarks while remaining genetically distinct. Indeed, SMA is caused by deletions or mutations in the surv ...

ELSEVIER SCIENCE BV2018

Characterizing human cytomegalovirus reinfection in congenitally infected infants: an evolutionary perspective

Kristen Kay Irwin, Jeffrey David Jensen, Susanne Petra Pfeifer, Cornelia Pokalyuk

Given the strong selective pressures often faced by populations when colonizing a novel habitat, the level of variation present on which selection may act is an important indicator of adaptive potential. While often discussed in an ecological context, this ...

Wiley2017

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Multiple organ dysfunction syndrome

A common NFKB1 variant detected through antibody analysis in UK Biobank predicts risk of infection and allergy

Countering T cell exhaustion and senescence for enhanced adoptive T cell therapies against solid tumors

Host genomics of SARS-CoV-2 infection

Rapid Progression of Kidney Dysfunction in People Living With HIV: Use of Polygenic and Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) Risk Scores

Disturbed mitochondrial dynamics in CD8(+)TILs reinforce T cell exhaustion

Comparative RNA-Seq analyses ofDrosophilaplasmatocytes reveal gene specific signatures in response to clean injury and septic injury

Early sepsis diagnosis via protein and miRNA biomarkers using a novel point-of-care photonic biosensor

Rapid and Digital Detection of Inflammatory Biomarkers Enabled by a Novel Portable Nanoplasmonic Imager

Pathogenic commonalities between spinal muscular atrophy and amyotrophic lateral sclerosis: Converging roads to therapeutic development

Characterizing human cytomegalovirus reinfection in congenitally infected infants: an evolutionary perspective

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Chat with Graph Search

Countering T cell exhaustion and senescence for enhanced adoptive T cell therapies against solid tumors

A common NFKB1 variant detected through antibody analysis in UK Biobank predicts risk of infection and allergy

Host genomics of SARS-CoV-2 infection

Disturbed mitochondrial dynamics in CD8(+)TILs reinforce T cell exhaustion

Rapid Progression of Kidney Dysfunction in People Living With HIV: Use of Polygenic and Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) Risk Scores

Rapid and Digital Detection of Inflammatory Biomarkers Enabled by a Novel Portable Nanoplasmonic Imager

Pathogenic commonalities between spinal muscular atrophy and amyotrophic lateral sclerosis: Converging roads to therapeutic development

Characterizing human cytomegalovirus reinfection in congenitally infected infants: an evolutionary perspective

Comparative RNA-Seq analyses ofDrosophilaplasmatocytes reveal gene specific signatures in response to clean injury and septic injury

Early sepsis diagnosis via protein and miRNA biomarkers using a novel point-of-care photonic biosensor