Publications related to Proteoglycan

Unraveling cartilage degeneration through synergistic effects of hydrostatic pressure and biomimetic temperature increase

Dominique Pioletti, Peyman Karami, Naser Nasrollahzadeh Mamaghani, Theofanis Stampoultzis, Yanheng Guo, Vijay Kumar Rana

Cartilage degeneration, typically viewed as an irreversible, vicious cycle, sees a significant reduction in two essential biophysical cues: the well-established hydrostatic pressure (HP) and the recently discovered transient temperature increase. Our study ...

Cambridge2023

Mimicking Loading-Induced Cartilage Self-Heating in Vitro Promotes Matrix Formation in Chondrocyte-Laden Constructs with Different Mechanical Properties

Dominique Pioletti, Peyman Karami, Naser Nasrollahzadeh Mamaghani, Theofanis Stampoultzis, Yanheng Guo

Articular cartilage presents a mechanically sensitive tissue. Chondrocytes, the sole cell type residing in the tissue, perceive and react to physical cues as signals that significantly modulate their behavior. Hyaline cartilage is a connective tissue with ...

2023

Cyclodextrin Modulated Type I Collagen Self-Assembly to Engineer Biomimetic Cornea Implants

Francesco Stellacci, Evangelia-Nefeli Athanasopoulou

Collagen-rich tissues in the cornea exhibit unique and highly organized extracellular matrix ultrastructures, which contribute to its high load-bearing capacity and light transmittance. Corneal collagen fibrils are controlled during development by small le ...

WILEY-V C H VERLAG GMBH2018

Large-Scale Chondroitin Sulfate Proteoglycan Digestion with Chondroitinase Gene Therapy Leads to Reduced Pathology and Modulates Macrophage Phenotype following Spinal Cord Contusion Injury

Bernard Schneider, Nicholas David James

Chondroitin sulfate proteoglycans (CSPGs) inhibit repair following spinal cord injury. Here we use mammalian-compatible engineered chondroitinase ABC (ChABC) delivered via lentiviral vector (LV-ChABC) to explore the consequences of large-scale CSPG digesti ...

Society for Neuroscience2014

Extracellular matrix components in peripheral nerve repair: how to affect neural cellular response and nerve regeneration?

Stéphanie Lacour, Alba Carla De Luca

Peripheral nerve injury is a serious problem affecting significantly patients' life. Autografts are the "gold standard" used to repair the injury gap, however, only 50% of patients fully recover from the trauma. Artificial conduits are a valid alternative ...

Shenyang Editorial Dept Neural Regeneration Res2014

Dendritic cell chemotaxis in 3D under defined chemokine gradients reveals differential response to ligands CCL21 and CCL19

Marco Pisano, Melody Swartz, Ulrike Haessler, Mingming Wu

Dendritic cell (DC) homing to the lymphatics and positioning within the lymph node is important for adaptive immunity, and is regulated by gradients of CCL19 and CCL21, ligands for CCR7. Despite the importance of DC chemotaxis, it is not well understood ho ...

2011

Pattern-Based Sensing of Sulfated Glycosaminoglycans with a Dynamic Mixture of Iron Complexes

Kay Severin

A dynamic mixture of iron complexes was used as a colorimetric sensor for sulfated glycosaminoglycans. The sensing ensemble was prepared by mixing [FeCl2(H2O)4] with dipicolylamine, the functionalized bipyridyl ligand N-(6-aminohexyl)-4'-methyl-2,2'-bipyri ...

Royal Society of Chemistry2010

Synthetic biomaterials as cell-responsive artificial extracellular matrices

Matthias Lütolf, Jeffrey Alan Hubbell

Cells in our tissues are exposed to complex arrays of biochemical and biophysical cues from their protein- and sugar-rich extracellular matrix (ECM). In concert with cell- intrinsic regulatory cascades, these temporally and spatially coordinated signals in ...

Imperial College Press2008

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Proteoglycan

Unraveling cartilage degeneration through synergistic effects of hydrostatic pressure and biomimetic temperature increase

Mimicking Loading-Induced Cartilage Self-Heating in Vitro Promotes Matrix Formation in Chondrocyte-Laden Constructs with Different Mechanical Properties

Cyclodextrin Modulated Type I Collagen Self-Assembly to Engineer Biomimetic Cornea Implants

Large-Scale Chondroitin Sulfate Proteoglycan Digestion with Chondroitinase Gene Therapy Leads to Reduced Pathology and Modulates Macrophage Phenotype following Spinal Cord Contusion Injury

Extracellular matrix components in peripheral nerve repair: how to affect neural cellular response and nerve regeneration?

Dendritic cell chemotaxis in 3D under defined chemokine gradients reveals differential response to ligands CCL21 and CCL19

Pattern-Based Sensing of Sulfated Glycosaminoglycans with a Dynamic Mixture of Iron Complexes

Synthetic biomaterials as cell-responsive artificial extracellular matrices

Effects of dynamic environments on extracellular morphogen gradients

C(1 -> 4)-linked disaccharides through carbonylative Stille cross-coupling

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Chat with Graph Search

Mimicking Loading-Induced Cartilage Self-Heating in Vitro Promotes Matrix Formation in Chondrocyte-Laden Constructs with Different Mechanical Properties

Effects of dynamic environments on extracellular morphogen gradients

Unraveling cartilage degeneration through synergistic effects of hydrostatic pressure and biomimetic temperature increase

Dendritic cell chemotaxis in 3D under defined chemokine gradients reveals differential response to ligands CCL21 and CCL19

Pattern-Based Sensing of Sulfated Glycosaminoglycans with a Dynamic Mixture of Iron Complexes

C(1 -> 4)-linked disaccharides through carbonylative Stille cross-coupling

Cyclodextrin Modulated Type I Collagen Self-Assembly to Engineer Biomimetic Cornea Implants

Synthetic biomaterials as cell-responsive artificial extracellular matrices

Large-Scale Chondroitin Sulfate Proteoglycan Digestion with Chondroitinase Gene Therapy Leads to Reduced Pathology and Modulates Macrophage Phenotype following Spinal Cord Contusion Injury

Extracellular matrix components in peripheral nerve repair: how to affect neural cellular response and nerve regeneration?