Concept

Osteogenesis imperfecta

Related publications (39)

An adaptive phase field approach to 3D internal crack growth in rocks

Alexandra Roma Larisa Kushnir, Tao Xu, Michael Heap

Modeling the 3D internal crack under compression entails complex fracture mechanics (mode I-II-III fracture), resulting in substantial computational costs and challenges in characterizing fracture morphology characterization for Phase Field Method (PFM) si ...

2024

Mode I fracture of thick adhesively bonded GFRP composite joints for wind turbine rotor blades

Véronique Michaud, Anastasios Vassilopoulos, Jialiang Fan

This article investigates the effects of voids, joint geometry, and test conditions on the quasi-static Mode I fracture performance of thick adhesive Double Cantilever Beam (DCB) joints such as those prevailing in wind industry and shipbuilding. The specim ...

2024

Association of a Polygenic Risk Score With Osteoporosis in People Living With HIV: The Swiss HIV Cohort Study

Jacques Fellay, Christian Axel Wandall Thorball

An individual polygenic risk score was associated with osteoporosis in people living with HIV. The genetic effect was robust, as it persisted after multivariable adjustment for established traditional and HIV-related osteoporosis risk factors, including te ...

OXFORD UNIV PRESS INC2023

Microtensile failure mechanisms in lamellar bone: Influence of fibrillar orientation, specimen size and hydration

Johann Michler, Daniele Casari, Tatiana Kochetkova

A mechanistic understanding of bone fracture is indispensable for developing improved fracture risk assessment in clinics. Since bone is a hierarchically structured material, gaining such knowledge requires analysis at multiple length scales. Here, the ten ...

ELSEVIER SCI LTD2021

User-driven walking assistance: first experimental results using the MyoSuit*

Wearable robots for the legs have been developed for gait rehabilitation training and as assistive devices. Most devices have been rigid exoskeletons designed to substitute the function of users who are completely paralyzed. While effective for this target ...

2019

Fatigue as the missing link between bone fragility and fracture

Dominique Pioletti, Vincent Stadelmann, Claire Acevedo

The prevention of fragility fractures in bone—pathologic fractures resulting from daily activity and mostly occurring in the elderly population—has been a long-term clinical quest. Recent research indicating that falls in the elderly might be the conse- qu ...

2018

SENSITIVITY ANALYSIS OF A PATIENT SPECIFIC FINITE ELEMENT MODEL FOR SHOULDER ARTHOPLASTY

Gerard Guell Bartrina

Background Glenohumeral osteoarthritis is common degenerative disease within the elderly population, which causes pain and reduced mobility. In advanced cases, total shoulder arthroplasty (TSA) is usually performed. Although TSA is an established procedure ...

2017

In vitro and in vivo investigation of bisphosphonate-loaded hydroxyapatite particles for peri-implant bone augmentation

Dominique Pioletti, Ulrike Kettenberger

Locally applied bisphosphonates, such as Zoledronate, have been shown in several studies to inhibit peri-implant bone resorption and recently to enhance peri-implant bone formation. Studies have also demonstrated positive effects of hydroxyapatite particle ...

Wiley-Blackwell2017

Osteogenesis imperfecta: from diagnosis and multidisciplinary treatment to future perspectives

Dominique Pioletti, Lee Ann Laurent-Applegate

Osteogenesis imperfecta is an inherited connective tissue disorder with wide phenotypic and molecular heterogen- eity. A common issue associated with the molecular ab- normality is a disturbance in bone matrix synthesis and homeostasis inducing bone fragil ...

Swiss Medical Publishers Ltd / EMH Swiss Medical Publishers2016

Potential blindness in children of patients with hereditary bone disease

Mono- and bi-allelic mutations in the low-density lipoprotein receptor related protein 5 (LRP5) may cause osteopetrosis, autosomal dominant and recessive exudative vitreoretinopathy, juvenile osteoporosis, or persistent hyperplastic primary vitreous (PHPV) ...

Springer London Ltd2016

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