Concept

Karyorrhexis

Summary
Karyorrhexis (from Greek κάρυον karyon 'kernel, seed, nucleus' and ῥῆξις rhexis 'bursting') is the destructive fragmentation of the nucleus of a dying cell whereby its chromatin is distributed irregularly throughout the cytoplasm. It is usually preceded by pyknosis and can occur as a result of either programmed cell death (apoptosis), cellular senescence, or necrosis. In apoptosis, the cleavage of DNA is done by Ca2+ and Mg2+ -dependent endonucleases. Image:nuclear changes.jpg|Morphological characteristics of pyknosis and other forms of nuclear destruction. File:Apoptotic neutrophil with nuclear fragmentation.jpg|Microscopy of an apoptotic neutrophil with nuclear fragmentation (H&E stain) See also *Karyolysis
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