Concept

Biology

Related publications (139)

Human needs as a driver for lighting design

Thanks to fundamental discoveries from neuroscience, biology and others, we have achieved a deeper understanding of how we interact with our environment. It is time to bring this knowledge back to architecture: we have access to the essential ingredients o ...

2013

From natural product to marketed drug: the tiacumicin odyssey

Jieping Zhu

The first members of the tiacumicin family of antibiotics, encompassing more than 40 compounds, were isolated in 1975. Structurally, the core aglycon is an 18-membered macrolactone having two conjugated diene units, one isolated double bond, 5 stereogenic ...

Royal Soc Chemistry2013

Sample processing device with detachable slide

Martinus Gijs, Ata Tuna Ciftlik

A biological and chemical sample processing device that b. comprises a high pressure-resistant, shallow and wide area microfluidic chamber having at least one wall formed by a detachable slide containing samples such as immobilized entities, biological sam ...

2013

Progesterone signalling in breast cancer: a neglected hormone coming into the limelight

Cathrin Brisken

Abstract | Understanding the biology of the breast and how ovarian hormones impinge on it is key to rational new approaches in breast cancer prevention and therapy. Because of the success of selective oestrogen receptor modulators (SERMs), such as tamoxife ...

Nature Publishing Group2013

Enlightening G-protein-coupled receptors on the plasma membrane using super-resolution photoactivated localization microscopy

Aleksandra Radenovic, Paolo Annibale, Marco Scarselli

The possibility to visualize and image the arrangement of proteins within the cell at the molecular level has always been an attraction for scientists in biological research. In particular, for signalling molecules such as GPCRs (G-protein-coupled receptor ...

Portland Press2013

Multiple Enhancers Regulate Hoxd Genes and the Hotdog LncRNA during Cecum Budding

Denis Duboule, Marion Leleu, Saskia Joëlle Delpretti Anex

Hox genes are required for the development of the intestinal cecum, a major organ of plant-eating species. We have analyzed the transcriptional regulation of Hoxd genes in cecal buds and show that they are controlled by a series of enhancers located in a g ...

Elsevier2013

Protein tag-mediated conjugation of oligonucleotides to recombinant affinity binders for proximity ligation

Kai Johnsson

While antibodies currently play a dominant role as affinity reagents in biological research and for diagnostics, a broad range of recombinant proteins are emerging as promising alternative affinity reagents in detection assays and quantification. DNA-media ...

Elsevier2013

Bacterial selection for nutrient removal in aerobic granular sludge wastewater treatment systems

Christof Holliger, David Gregory Weissbrodt

The mechanism of bacterial selection was investigated in aerobic granular sludge wastewater treatment systems (i) to determine why biological nutrient removal (BNR) gets deteriorated during granulation start-up under wash-out dynamics, and (ii) to identify ...

2013

Differences in the Concept of Fitness Between Artificial Evolution and Natural Selection

Dario Floreano, Laurent Keller, Pawel Lichocki

Evolutionary algorithms were proposed to automatically find solutions to computational problems, much like evolution discovers new adaptive traits. Lately, they have been used to address challenging questions about the evolution of modularity, the genetic ...

The MIT Press2012

The biology of personalized cancer medicine: facing individual complexities underlying hallmark capabilities

Michele De Palma, Douglas Hanahan

It is a time of great promise and expectation for the applications of knowledge about mechanisms of cancer toward more effective and enduring therapies for human disease. Conceptualizations such as the hallmarks of cancer are providing an organizing princi ...

2012

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