Concept

Coiled coil

Related publications (32)

A nonradial coarse-grained potential for proteins produces naturally stable secondary structure elements

Matteo Dal Peraro, Michele Cascella, Davide Alemani, Francesca Collu

We introduce a nonradial potential term for coarse-grained (CG) molecular simulations of proteins. This term mimics the backbone dipole−dipole interactions and accounts for the needed directionality to form stable folded secondary structure elements. We sh ...

2010

Cryoelectron microscopy structure of purified gamma-secretase at 12 A resolution

Lorène Aeschbach, Patrick Fraering, Hua Li

Gamma-secretase, an integral membrane protein complex, catalyzes the intramembrane cleavage of the beta-amyloid precursor protein (APP) during the neuronal production of the amyloid beta-peptide. As such, the protease has emerged as a key target for develo ...

Elsevier2009

Solution behavior of peptide and peptide-hybrid materials

Harald Nuhn

Peptide based and peptide hybrid materials represent two interesting and challenging classes of biomaterials. Both classes consist of and contain, respectively, one or more polypeptide blocks, endowing the resulting polymers with enhanced self-assembly pro ...

EPFL2008

An engineered protein tag for multi-protein labeling in living cells

Kai Johnsson, Christian Heinis, Alexandre Juillerat

The visualization of complex cellular processes involving multiple proteins requires the use of spectroscopically distinguishable fluorescent reporters. We have previously introduced the SNAP-tag as a general tool for the specific labeling of SNAP-tag fusi ...

2008

Oligomeric structure of the Bacillus subtilis cell division protein DivIVA determined by transmission electron microscopy

Henning Paul-Julius Stahlberg, Andreas Engel

DivIVA from Bacillus subtilis is a bifunctional protein with distinct roles in cell division and sporulation. During vegetative growth, DivIVA regulates the activity of the MinCD complex, thus helping to direct cell division to the correct mid-cell positio ...

Wiley-Blackwell2004

Self-assembly and dynamics of poly(γ-benzyl-L-glutamate) peptides

Harm-Anton Klok

The structure and the associated dynamics have been investigated in a series of oligopeptides of γ-benzyl-L-glutamate using DSC, WAXS, FTIR, NMR and dielectric spectroscopy, and rheology, respectively. The peptides with degrees of polymerization below 18 a ...

2004

Reversible self-organization of poly(ethylene glycol)-based hybrid block copolymers mediated by a de novo four-stranded α-helical coiled coil motif

Harm-Anton Klok

This paper describes the synthesis and supramolecular organization of two novel hybrid diblock copolymers based on poly(ethylene glycol) (PEG) and peptide sequences inspired by the coiled coil protein folding motif. The self-organization of the diblock cop ...

2003

Small-angle neutron scattering from diblock copolymer poly(styrene-d8)-b-poly(γ-benzyl L-glutamate) solutions: Rod-coil to coil-coil transition

Harm-Anton Klok

The elastic properties of rod-coil diblock copolymer poly(styrene-d8)-b-poly(γ-benzyl L-glutamate) (PSd-b-PBLG) rod-coil diblock copolymer solutions were investigated using small-angle neutron scattering (SANS). PBLG is known to undergo a transition from a ...

2003

Protein design and folding: Template trapping of self-assembled helical bundles

An experimental system is described, permitting a detailed and systematic analysis of the factors governing self-assembly of amphipathic helices, e.g. to a four-helical bundle, a subject of major relevance for tertiary structure formation. protein folding ...

2001

Peptide folding: when simulation meets experiment

Karl Gademann

Mol. dynamics simulation studies on the folding of beta-peptides H-beta3-HVal-beta3-HAla-beta3-HLeu-(S,S)-beta3-HAla(alphaMe)-beta3-HVal-beta3-HAla-beta3-HLeu-OH and H-beta2-HVal-beta3-HAla-beta2-HLeu-beta3-HVal-beta2-HAla-beta3-HLeu-OH were carried out. D ...

1999

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