Publications related to Autoimmunity

The orphan nuclear receptor LRH-1/NR5a2 critically regulates T cell functions

LRH-1 (liver receptor homolog-1/NR5a2) is an orphan nuclear receptor, which regulates glucose and lipid metabolism, as well as intestinal inflammation via the transcriptional control of intestinal glucocorticoid synthesis. Predominantly expressed in epithe ...

American Association for the Advancement of Science (AAAS)2019

Nucleic acids presenting polymer nanomaterials as vaccine adjuvants

Maartje Martina Cornelia Bastings, Kaltrina Paloja, Alice Comberlato

Most vaccines developed today include only the antigens that best stimulate the immune system rather than the entire virus or microbe, which makes vaccine production and use safer and easier, though they lack potency to induce acceptable immunity and long- ...

ROYAL SOC CHEMISTRY2019

Effect of Fc Receptor Genetic Diversity on HIV-1 Disease Pathogenesis

Jacques Fellay, Christian Axel Wandall Thorball

Fc receptor (FcR) genes collectively have copy number and allelic polymorphisms that have been implicated in multiple inflammatory and autoimmune diseases. This variation might also be involved in etiology of infectious diseases. The protective role of Fc- ...

2019

Redox-responsive interleukin-2 nanogel specifically and safely promotes the proliferation and memory precursor differentiation of tumor-reactive T-cells

Li Tang, Lixia Wei, Yuqing Xie, Hacer Arik

Interleukin-2 (IL-2) is a potent T-cell mitogen that can adjuvant anti-cancer adoptive T-cell transfer (ACT) immunotherapy by promoting T-cell engraftment. However, the clinical applications of IL-2 in combination with ACT are greatly hindered by the sever ...

2019

Dynamic Evolution of Antimicrobial Peptides Underscores Trade-Offs Between Immunity and Ecological Fitness

Bruno Lemaitre, Mark Austin Hanson

There is a developing interest in how immune genes may function in other physiological roles, and how traditionally non-immune peptides may, in fact, be active in immune contexts. In the absence of infection, the induction of the immune response is costly, ...

FRONTIERS MEDIA SA2019

Absence of specific alternatively spliced exon of CD44 in macrophages prevents colitis

Ulrich Hoffmann

CD44 is a transmembrane molecule appearing in numerous isoforms generated by insertions of alternatively spliced variant exons (CD44v) and having various binding partners. CD44v7 on T cells was proposed to promote colitis by preventing T-cell apoptosis. He ...

NATURE PUBLISHING GROUP2018

Bioengineering strategies for inducing tolerance in autoimmune diabetes

Jeffrey Alan Hubbell, Steinunn Baekkeskov Hanahan, Edward Allen Phelps

Type 1 diabetes is an autoimmune disease marked by the destruction of insulin-producing beta cells in the pancreatic islets. Strategies to delay onset or prevent the autoimmune recognition of beta cell antigens or T cell-mediated killing of beta cells have ...

Elsevier Science Bv2017

Primary human and rat beta cells release the intracellular autoantigens GAD65, IA-2 and proinsulin in exosomes together with cytokine-induced enhancers of immunity

Michele De Palma, Davide Demurtas, Romain Hamelin, Jeffrey Alan Hubbell, Melody Swartz, Steinunn Baekkeskov Hanahan, Sachiko Hirosue, Chiara Cianciaruso, Miriella Carmela Pasquier, Edward Allen Phelps

The target autoantigens in several organ-specific autoimmune diseases, including type 1 diabetes (T1D), are intracellular membrane proteins, whose initial encounter with the immune system is poorly understood. Here we propose a new model for how these prot ...

American Diabetes Association2017

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Autoimmunity

The orphan nuclear receptor LRH-1/NR5a2 critically regulates T cell functions

Nucleic acids presenting polymer nanomaterials as vaccine adjuvants

Effect of Fc Receptor Genetic Diversity on HIV-1 Disease Pathogenesis

Redox-responsive interleukin-2 nanogel specifically and safely promotes the proliferation and memory precursor differentiation of tumor-reactive T-cells

Dynamic Evolution of Antimicrobial Peptides Underscores Trade-Offs Between Immunity and Ecological Fitness

New insights on Drosophila antimicrobial peptide function in host defense and beyond

The metabolite BH4 controls T cell proliferation in autoimmunity and cancer

Absence of specific alternatively spliced exon of CD44 in macrophages prevents colitis

Bioengineering strategies for inducing tolerance in autoimmune diabetes

Primary human and rat beta cells release the intracellular autoantigens GAD65, IA-2 and proinsulin in exosomes together with cytokine-induced enhancers of immunity

Graph Chatbot

Chat with Graph Search

Dynamic Evolution of Antimicrobial Peptides Underscores Trade-Offs Between Immunity and Ecological Fitness

Nucleic acids presenting polymer nanomaterials as vaccine adjuvants

The metabolite BH4 controls T cell proliferation in autoimmunity and cancer

Effect of Fc Receptor Genetic Diversity on HIV-1 Disease Pathogenesis

The orphan nuclear receptor LRH-1/NR5a2 critically regulates T cell functions

New insights on Drosophila antimicrobial peptide function in host defense and beyond

Absence of specific alternatively spliced exon of CD44 in macrophages prevents colitis

Redox-responsive interleukin-2 nanogel specifically and safely promotes the proliferation and memory precursor differentiation of tumor-reactive T-cells

Primary human and rat beta cells release the intracellular autoantigens GAD65, IA-2 and proinsulin in exosomes together with cytokine-induced enhancers of immunity

Bioengineering strategies for inducing tolerance in autoimmune diabetes