Publications related to Autoimmunity

NCoR1 restrains thymic negative selection by repressing Bim expression to spare thymocytes undergoing positive selection

Johan Auwerx, Shuo Zhang, Na Zhang, Hui Xiao, Ye Zheng

Thymocytes must pass both positive and negative selections to become mature T cells. Negative selection purges thymocytes whose T-cell receptors (TCR) exhibit high affinity to self-peptide MHC complexes (self pMHC) to avoid autoimmune diseases, while posit ...

Nature Publishing Group2017

Interactions between fibroblastic reticular cells and B cells promote mesenteric lymph node lymphangiogenesis

Nicola Harris, Lalit Kumar Dubey, Praneeth Karempudi

Lymphatic growth (lymphangiogenesis) within lymph nodes functions to promote dendritic cell entry and effector lymphocyte egress in response to infection or inflammation. Here we demonstrate a crucial role for lymphotoxin-beta receptor (LT beta R) signalin ...

Springer Nature2017

Matrix-binding checkpoint immunotherapies enhance antitumor efficacy and reduce adverse events

Jeffrey Alan Hubbell, Melody Swartz, Hans Mattias Larsson, Lambert Charles François Potin, Gabriele Galliverti, Jun Ishihara, Kazuto Fukunaga

Immune checkpoint blockade exhibits considerable antitumor activity, but previous studies have reported instances of severe treatment-related adverse events. We sought to explore local immune checkpoint blockade, with an antibody (Ab) form that would be re ...

Amer Assoc Advancement Science2017

Remote Control of Intestinal Stem Cell Activity by Haemocytes in Drosophila

Bruno Lemaitre, Jean Philippe Boquete, Jan Paul Dudzic, Sveta Chakrabarti, Xiaoxue Li, Esther Jeanne Collas

The JAK/STAT pathway is a key signaling pathway in the regulation of development and immunity in metazoans. In contrast to the multiple combinatorial JAK/STAT pathways in mammals, only one canonical JAK/STAT pathway exists in Drosophila. It is activated by ...

Public Library of Science2016

1,2,3-Triazoles as inhibitors of indoleamine 2,3-dioxygenase 2 (IDO2)

Pierre Vogel, George Coukos, Somi Reddy Majjigapu, Olivier Michielin

Indoleamine 2,3-dioxygenase 2 (IDO2) is a potential therapeutic target for the treatment of diseases that involve immune escape such as cancer. In contrast to IDO1, only a very limited number of inhibitors have been described for IDO2 due to inherent diffi ...

Pergamon-Elsevier Science Ltd2016

Structure of Crenezumab Complex with A beta Shows Loss of beta-Hairpin

Andrea Pfeifer, Andreas Muhs, Bing Li

Accumulation of amyloid-beta (A beta) peptides and amyloid plaque deposition in brain is postulated as a cause of Alzheimer's disease (AD). The precise pathological species of A beta remains elusive although evidence suggests soluble oligomers may be prima ...

Nature Publishing Group2016

The role of cGAS in innate immunity and beyond

Andrea Ablasser, Muhammet Fatih Gülen

The sensing of foreign DNA is crucial for host defense against several pathogens. In the cytosol the enzyme cyclic GMP-AMP synthase (cGAS) is critical for the recognition of pathogen-derived DNA and provides key signals that initiate immune responses. Beyo ...

2016

MicroRNA Profile in CD8+T-Lymphocytes from HIV-Infected Individuals: Relationship with Antiviral Immune Response and Disease Progression

Evaristo Jose Planet Letschert

Background The relationship between host microRNAs (miRNA), viral control and immune response has not yet been elucidated in the field of HIV. The aim of this study was to assess the differential miRNA profile in CD8+ T-cells between HIV-infected individua ...

Public Library of Science2016

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Autoimmunity

Ganciclovir derivatives for modulating innate and adaptive immunity and for use in immunotherapy

NCoR1 restrains thymic negative selection by repressing Bim expression to spare thymocytes undergoing positive selection

Investigating the Biological Mechanisms underlying the Initiation of Autoimmunity against Beta Cell Antigens in Type 1 Diabetes

Interactions between fibroblastic reticular cells and B cells promote mesenteric lymph node lymphangiogenesis

Matrix-binding checkpoint immunotherapies enhance antitumor efficacy and reduce adverse events

Remote Control of Intestinal Stem Cell Activity by Haemocytes in Drosophila

1,2,3-Triazoles as inhibitors of indoleamine 2,3-dioxygenase 2 (IDO2)

Structure of Crenezumab Complex with A beta Shows Loss of beta-Hairpin

The role of cGAS in innate immunity and beyond

MicroRNA Profile in CD8+T-Lymphocytes from HIV-Infected Individuals: Relationship with Antiviral Immune Response and Disease Progression

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Chat with Graph Search

Investigating the Biological Mechanisms underlying the Initiation of Autoimmunity against Beta Cell Antigens in Type 1 Diabetes

Ganciclovir derivatives for modulating innate and adaptive immunity and for use in immunotherapy

1,2,3-Triazoles as inhibitors of indoleamine 2,3-dioxygenase 2 (IDO2)

Structure of Crenezumab Complex with A beta Shows Loss of beta-Hairpin

The role of cGAS in innate immunity and beyond

MicroRNA Profile in CD8+T-Lymphocytes from HIV-Infected Individuals: Relationship with Antiviral Immune Response and Disease Progression

NCoR1 restrains thymic negative selection by repressing Bim expression to spare thymocytes undergoing positive selection

Interactions between fibroblastic reticular cells and B cells promote mesenteric lymph node lymphangiogenesis

Remote Control of Intestinal Stem Cell Activity by Haemocytes in Drosophila

Matrix-binding checkpoint immunotherapies enhance antitumor efficacy and reduce adverse events