Concept
Substituent
Related publications (97)
Novel Alkynylation Methods through the Combination of Hypervalent Iodine Reagents and Alkynyl-trifluoroborate Salts
The alkyne motif is a versatile functional group often encountered in organic chemistry. It can be involved in various transformations such as the alkyne-azide cycloaddition and has found widespread application in medicinal chemistry, chemical biology and ...
EPFL2024Origin of metallic-like behavior in disordered carbon nano-onions
Oleg Yazyev, Kristians Cernevics
Carbon nano-onions are a class of nanomaterials that can exhibit long electron spin relaxation times at room temperature and thus hold promise as potential building blocks for spintronics and quantum information processing devices. Despite first being synt ...
PERGAMON-ELSEVIER SCIENCE LTD2023Synthesis of Four-Membered BN3 Heterocycles by the Borylation of Triazenes
Rosario Scopelliti, Kay Severin, Abdusalom Suleymanov
Borylated triazenes were synthesized by the dehydrocoupling of triazenes with 9-borabicyclo(3.3.1)nonane, by the condensation of triazenes with BEt3, or by the reaction of sodium triazenides with dialkyl- or diarylboron halides. The structures of the produ ...
2022New Vinylation and Alkynylation Strategies with Hypervalent Iodine Reagents and Diazo Compounds
The development of a sequential copper-catalyzed oxy-alkynylation/intramolecular [4+2] cycloaddition of allenes and arenes was investigated at first. This one-pot protocol allowed the construction of complex polycylic architectures with high efficiency fro ...
EPFL2021New Strategies for the Functionalization of Alkenes Exploiting Tethering Chemistry and Ring Strain
Bastian Antoine Rodolphe Claude Muriel
Amino alcohols, cyclopropanes and nitriles are privileged structural motifs found in the scaffold of natural products and bioactive compounds. In addition, they are versatile building blocks in organic chemistry. The development of new and increasingly eff ...
EPFL2021Ligand Effects in Low-Valent Co(I) Clathrochelate Complexes
Rosario Scopelliti, Kay Severin, Farzaneh Fadaei Tirani, Ophélie Marie Planes
Clathrochelate complexes of cobalt are known in the oxidation states I, II, and III. Low-valent Co(I) complexes are highly reactive compounds, and there is only limited knowledge about their structures in the solid state. Herein, we describe the crystallog ...
WILEY-V C H VERLAG GMBH2021Combining cryognic ion spectroscopy with ion mobility for the study of glycan fragmentation
The importance of glycans in biological processes are matched by their structural complexity. Coating the surfaceof most living cells, glycans play key roles in many biological processes, and the role they play is closely relatedto their structures. Struct ...
EPFL2021A new approach for identifying positional isomers of glycans cleaved from monoclonal antibodies
Thomas Rizzo, Ahmed Ben Faleh, Stephan Warnke, Priyanka Bansal, Vasyl Yatsyna, Natalia Yalovenko
Glycosylation patterns in monoclonal antibodies (mAbs) can vary significantly between different host cell types, and these differences may affect mAbs safety, efficacy, and immunogenicity. Recent studies have demonstrated that glycan isomers with the termi ...
ROYAL SOC CHEMISTRY2021Probing Substrate Scope with Molecular Volcanoes
Matthew Wodrich, Boodsarin Sawatlon
Molecular volcano plots, a tool generally used to identify ideal catalysts for a given chemical transformation, are employed in an alternative fashion to examine the substrate scope by revealing the range of substrates that can be accommodated by a single ...
AMER CHEMICAL SOC2020Synthetic Studies toward Amanita Phalloides Toxins
Philipp Georg Werner Seeberger
Amatoxins are ribosomally synthesized and post-translationally modified bicyclic octapeptides biosynthesized by the deadly basidiomycete fungus Amanita phalloides. Amongst this group, alpha-amanitin is the most widely known toxin and is currently under inv ...
EPFL2020