Concept

Interneuron

Related publications (134)

Optogenetic Probing of Cortical Synaptic Circuits Measured Through in Vivo Whole-Cell Recordings in the Mouse Barrel Cortex

Although neocortex underlies higher-order brain functions, little is known about the synaptic interactions that drive neocortical microcircuit function in vivo. The neocortex is spontaneously active in vivo so I explored how such spontaneous network activi ...

EPFL2011

Variational Learning for Recurrent Spiking Networks

Wulfram Gerstner, Danilo Jimenez Rezende, Daniël Pieter Wierstra

We derive a plausible learning rule updating the synaptic efficacies for feedforward, feedback and lateral connections between observed and latent neurons. Operating in the context of a generative model for distributions of spike sequences, the learning me ...

2011

Membrane potential dynamics of GABAergic neurons in the barrel cortex of behaving mice

Carl Petersen, Michael Avermann, Ferenc Mátyás

Computations in cortical circuits are mediated by synaptic interactions between excitatory and inhibitory neurons, and yet we know little about their activity in awake animals. Here, through single and dual whole-cell recordings combined with two-photon mi ...

Elsevier2010

Brief Bursts Self-Inhibit and Correlate the Pyramidal Network

Henry Markram, Rodrigo de Campos Perin, Thomas Berger, Gilad Silberberg

Inhibitory pathways are an essential component in the function of the neocortical microcircuitry. Despite the relatively small fraction of inhibitory neurons in the neocortex, these neurons are strongly activated due to their high connectivity rate and the ...

Public Library of Science2010

Cell loss in the motor and cingulate cortex correlates with symptomatology in Huntington's disease

Doris Chau Voo Thu

Huntington's disease is an autosomal dominant inherited neurodegenerative disease with motor symptoms that are variably co-expressed with mood and cognitive symptoms, and in which variable neuronal degeneration is also observed in the basal ganglia and the ...

Oxford University Press2010

Sound-driven modulation of sub- and suprathreshold activity in mouse primary visual cortex

Diego Ghezzi

Integration of multimodal information is essential for the integrative response of the brain and is thought to be accomplished mostly in sensory association areas. However, available evidences in humans and monkeys indicate that this process begins already ...

2010

Interpretation of neuronal response properties with simplified neuron models

Laurent Badel

Computational neuroscience is a branch of the neurosciences that attempts to elucidate the principles underlying the operation of neurons with the help of mathematical modeling. In contrast with a number of fields pursuing a tightly related goal, such as m ...

EPFL2009

Modeling the effects of midazolam on cortical and thalamic neurons

Sean Lewis Hill

Controversy exists regarding the site where anesthetics act in the brain to produce sedation and unconsciousness. Actions in the cerebral cortex and thalamus are likely, although the relative importance of each site is unclear. We used in computo modeling ...

2009

Targeted overexpression of the parkin substrate Pael-R in the nigrostriatal system of adult rats to model Parkinson's disease

Patrick Aebischer, Bernard Schneider, Jean-Charles Bensadoun, Julien Dusonchet

Loss of function of parkin, an ubiquitin ligase, is responsible for autosomal recessive juvenile parkinsonism (AR-JP). Parkin-associated endothelin receptor-like receptor (Pael-R) was identified as an authentic substrate of parkin and is thought to accumul ...

2009

Petilla terminology: nomenclature of features of GABAergic interneurons of the cerebral cortex

Henry Markram, Carl Petersen, Yun Wang, Ruth Benavides Piccione, Jean Rossier, Lidia Alonso-Nanclares

Neuroscience produces a vast amount of data from an enormous diversity of neurons. A neuronal classification system is essential to organize such data and the knowledge that is derived from them. Classification depends on the unequivocal identification of ...

2008

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