Protein-Protein Interaction Networks

This lecture delves into the significance of protein-protein interaction networks in controlling cellular processes, emphasizing the mapping of interactions across different organisms. It explores the importance of binding in cellular processes, experimental approaches like Tandem Affinity Purification, and the limitations of traditional biochemical techniques. The lecture also covers peptide sequencing by ESI-MSMS, the purification of protein complexes, and the construction of interaction networks. It discusses the identification of drug targets through protein-protein interaction maps, highlighting the challenges and implications of these findings.