Lecture
This lecture covers the cell signalling mechanisms in eukaryotic cells, focusing on G proteins and Ras. It explains how G proteins function as on/off switches by binding to GDP or GTP, and how Ras mediates the transition between active and inactive signalling states. The regulation of signalling via Ras by GEF and GAP proteins is also discussed, along with the role of GTPases in propagating signals within the cell. Additionally, the lecture explores the activation of cell signalling through receptor tyrosine kinases, detailing the transphosphorylation process and the assembly of protein complexes that drive cellular signalling. The connection between Ras signalling and the activation of tyrosine kinase receptors is elucidated, emphasizing the importance of adaptor proteins in linking these pathways.