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This lecture covers the signaling pathways involving tyrosine kinases and Ras, focusing on the activation and inactivation mechanisms of Ras-GTPase, the role of effectors like RAF and AKT, and the use of lipids as signaling molecules. It also discusses the dysregulation of these pathways in cancer, the feedback mechanisms to stop signaling, and compares signal transduction in prokaryotes and eukaryotes.