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This lecture covers the methodology of Material Flow Analysis (MFA) with a focus on economy-wide and regional applications. It includes topics such as spatial flow analysis, input-output models, and environmentally extended IO analysis. The instructor presents worked-out examples to illustrate concepts like total output per industry and energy use per sector. The lecture also delves into the concepts of value added and the complete input-output model. Furthermore, it explores the relationship between monetary and physical 10 tables, emphasizing the importance of balanced MSUT and PSUT tables. The presentation concludes with recommendations on 10 tables to work with, including the EXIOBASE Multi-regional EEIO DB and Swiss IOA Projects.