Gas Chromatography Optimization

This lecture covers the optimization criteria for gas chromatography, focusing on factors influencing separation such as chemical and physical aspects of the column. It discusses the impact of column length, internal diameter, and stationary phase film thickness on efficiency and resolution. The lecture also delves into the influence of carrier gas viscosity, temperature programming, and stationary phase polarity on chromatographic performance. Additionally, it explores the use of temperature programming mode, retention indices, and interpretation of mass spectra in GC analysis. Practical applications, such as two-dimensional GC and chemical derivatization, are also discussed.