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This lecture delves into the history of Brownian Motion, from Robert Brown's observations in 1827 to Perrin's experiments in 1908, which confirmed the molecular nature of matter. It explores Langevin's explanation, Einstein's solution, and the mathematical models of random walks. The implications of Brownian motion in cell biology, the stochastic differential equations, and the various experimental techniques to measure Brownian motion are also discussed. The lecture concludes by highlighting the significance of noise in cellular processes and the balance between conservation and transport in a cell.