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This lecture covers the fundamental aspects of DNA structure, including the organization of chromosomes, the role of histones, and the process of DNA replication. The instructor explains the concept of antiparallel strands, base pairing, and the semi-conservative nature of DNA replication. The lecture also delves into the importance of the major and minor grooves in DNA, the forces involved in DNA stability, and the specific enzymes responsible for DNA replication. Additionally, the lecture touches on the different types of DNA structures and the significance of purine-pyrimidine pairing. The intricate details of nucleotide structure, phosphodiester bonds, and the polymerase activity during replication are thoroughly discussed.