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This lecture covers the physical models for micro and nanosystems, focusing on microsystems for biology, including examples like microarrays and nanopores. It delves into the characteristics of ideal fluids, continuity equations for steady flow, and the general Navier-Stokes equations for fluid dynamics. The instructor explains the concept of incompressible fluids and the simplifications made to solve the Navier-Stokes equations. The lecture also discusses the Reynolds number, boundary conditions for fluid flow, and the application of molecular dynamics simulations in understanding fluid behavior.