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This lecture covers the regulation of the digestive system, focusing on the absorption and metabolism of lipids. It discusses the structure of lipids, the role of bile salts in lipid solubilization, absorption of lipids, formation of chylomicrons and VLDL, absorption of water and Na+ in the digestive tract, regulation of Ca++ absorption by the duodenum, absorption of Fe++, capture of folic acid, absorption of vitamin B12, and metabolism of glucose, fatty acids, amino acids, urea, and cholesterol. The lecture also explores the synthesis of bile acids, detoxification function of the liver, and the formation of ketone bodies from acetyl-CoA.