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This lecture by the instructor covers the foreign body reaction (FBR) to implants, focusing on the performance of current implantable neural interfaces, investigation methods of FBR in vivo, strategies to modulate FBR, and implant failure. It discusses the acute phase of implant insertion, the impact on perfusion and blood flow, blood-brain barrier (BBB) rupture, repair processes, imaging techniques, and cell staining for visualizing neural tissue.