Deep Brain Stimulation: Network Effects and Connectivity

This lecture explores the network effects of deep brain stimulation (DBS) beyond the basal ganglia, focusing on the optimal functional and structural connectivity. It delves into the imaging of networks and tracts stimulated by DBS, revealing the regions and anatomical tracts engaged in therapeutic effects. The lecture discusses the enhancement of activity in the subthalamic nucleus (STN) and thalamus by DBS, as well as the interference with brain activity in a large network. It also covers the importance of focal DBS of specific structures within the STN to minimize adverse side effects. Additionally, the role of brain oscillations, particularly beta oscillations, in PD motor symptoms and the therapeutic effects of STN-DBS are examined.