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Explores the impact of machine learning in understanding human diseases, focusing on historical significance, natural products discovery, and challenges in designer drugs.
Covers enzyme inhibition mechanisms, drug modes of action, targeted protein degradation using PROTACs, and the bump-hole method for protein-ligand engineering.
Covers the basics of proteomics, mass spectrometry, protein synthesis, and amino acids, emphasizing the importance of molecular weight and isotopic abundance.
Explores molecular glues as new drug modalities, focusing on binding forces, energetics, biomolecular interactions, quantification, drug development, and structural characterization.
Covers the design and analysis of inhibitors for next-generation covalent drugs, focusing on target engagement and the importance of cysteine targeting.
