Pharmacokinetics Modeling: Zero and First-Order Kinetics

This lecture covers the fundamental concepts of pharmacokinetics modeling, focusing on zero-order kinetics where drug processes occur at a constant rate and first-order kinetics where the rate is proportional to drug concentration. It explains the implications of saturation in zero-order kinetics and the linear relationship in first-order kinetics. The lecture also delves into compartment models, including single and multiple compartments, to understand drug distribution within the body. Key parameters such as the apparent volume of distribution, elimination rate constant, and clearance are discussed in detail, along with practical exercises on dosage calculations and achieving steady-state drug concentrations.