This lecture discusses the integration of neuroprosthetics and sensory feedback mechanisms for limb control. It begins with an overview of spinal cord stimulation and its clinical applications, highlighting the evolution of sensory restoration techniques over time. The instructor explains the role of the cuneate nucleus in processing tactile and proprioceptive information, emphasizing the challenges of surgical implantation in this area. The lecture further explores the somatosensory cortex's involvement in sensory feedback and motor control, detailing the complexities of implanting electrodes in various brain regions. The discussion includes insights from recent studies demonstrating the potential for closed-loop systems that combine motor commands and sensory feedback to improve prosthetic control. The instructor also addresses the importance of biomimetic stimulation patterns and the use of multiple electrodes to enhance the richness of sensory experiences. The lecture concludes with a summary of the various approaches to neuroprosthetic control, emphasizing the need for tailored solutions based on individual patient needs and capabilities.