Protein Aggregation Control

This lecture covers the principles of control theory applied to the regulation of protein aggregation, including optimal control strategies, reinforcement learning, and inhibitors. It explores the microscopic mechanisms of aggregation, the impact of drug interventions, and the role of liquid compartments in spatially controlling aggregation. The instructor discusses the challenges of targeting aberrant protein aggregation in various diseases and presents research on the optimal drug protocols. The lecture also delves into the interplay between aggregation kinetics and phase separation, highlighting how droplets can influence the number and size of aggregates. Additionally, it examines how droplet rheology affects aggregate distribution and mobility, showcasing the complex dynamics of protein aggregation control.