Chaperone-Mediated Disaggregation: Amyloid Fibrils and Hsp70

This lecture discusses the disaggregation of amyloid fibrils by the human Hsp70 chaperone, focusing on protein folding, quality control, and the role of chaperones in preventing and promoting aggregate formation in neurodegenerative diseases like Alzheimer's and Parkinson's. The presentation covers the stages of amyloid aggregation, the impact of chaperones on disaggregation, and the specific interactions between chaperones and amyloid fibrils. The lecture also explores the chaperone machinery, including the Hsp70 chaperone system and the involvement of J-domain proteins. Various experiments and models are presented to illustrate the mechanisms behind chaperone-mediated disaggregation.