DNA Damage Response and Tumor Suppressor Genes

This lecture covers the role of P53 in cancer, distinguishing between driver and passenger mutations, testing mutant genes, and identifying proteins involved in DNA damage response. It also explores the consequences of DNA damage during the cell cycle, the function of tumor suppressor genes like ARF and ATR, and the experimental approaches to study mutated P53. The instructor discusses methods such as complementation experiments, electromobility shift assays, and RNA-seq to understand the effects of mutations on P53 and other tumor suppressor genes.