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This lecture delves into the detailed modeling of ion channels and neuronal morphologies, focusing on the Blue Brain Project's work on in silico neuroscience. Topics covered include the composition of detailed neuronal models, ion channel kinetics, and the reconstruction of morphologies. The lecture also explores the classification of neurons based on anatomical, physiological, and molecular features, as well as the localization and behavior of different neuron classes. The discussion extends to the complexity of neuron types, the mapping of neuronal structures, and the experimental observations related to neuronal firing patterns and responses.