Understanding Tau Pathologies

This lecture delves into the complexities of Tau pathologies, focusing on the role of Tau in Alzheimer's disease and related neurodegenerative disorders. It covers the mechanisms of Tau hyperphosphorylation, propagation, and aggregation, as well as the impact on cognitive decline. The discussion extends to the genetic associations, biomarkers, and therapeutic interventions targeting Tau. The presentation also explores the spread of Tau pathology in aging brains and the implications for neuroinflammation. Additionally, it addresses the prion-like behavior of Tau, its physiological functions, and the significance of misfolded Tau in various CNS diseases.