Nuclear Receptors: Structure and Evolution

This lecture covers the basic structure of steroid hormones, the role of nuclear hormone receptors in molecular endocrinology, and the evolution of vertebrate steroid hormone receptors from a common ancestor. It discusses the key mutations identified in resurrected proteins, common nuclear receptors and their ligands, and the DNA binding and ligand binding domains. The lecture also explains the response elements for nuclear receptors, heterodimeric and homodimeric nuclear receptors, and the nuclear receptor family classification.