This lecture discusses the collaborative grand challenge of assistive distributed robotics at EPFL, aiming to provide higher autonomy and quality of life for individuals with limited mobility. It covers topics such as smart assistive environments, rehabilitation robots, smart homes, Internet of Things, and human-robot interaction. The lecture emphasizes the importance of machine learning, distributed intelligence, real-time computing, and design ergonomics in this field. It also highlights the strong societal impact and educational opportunities that arise from collaborative research projects involving various labs within the Center for Intelligent Systems.