Heat Shock Transcription Factors: Regulation and Targets

This lecture by the instructor covers the regulation and targets of Heat Shock Transcription Factors (HSFs) in response to Heat Shock and Oxidative Stress. The content includes the identification of HSF2 as a transcription factor, the isolation of HSF2 cDNA, and the role of HSFs in stress responses across different organisms. The lecture delves into the mechanisms of stress response, the isolation of distinct HSF genes in humans, and the post-translational modifications of HSFs. It also explores the dynamic expression of HSF2 in various cellular contexts and its impact on cell adhesion and EMT. The lecture concludes with insights into the transcriptional memory and re-programming of transcription by repeated stress exposures.