This lecture introduces the key theme of research in immunoengineering, covering basic principles and cutting-edge research. The instructor and guest lecturers present their expertise, emphasizing communication methods and course logistics. The course schedule, assessment methods, and recommended resources are detailed, along with an overview of the immune system and immune cell functions. The lecture also discusses the differentiation of B and T cells, immune responses, and vaccination strategies. Various immune system components, such as antibodies, T cells, and antigen-presenting cells, are explained in detail, along with examples of autoimmune diseases and mechanisms of immune tolerance.