Membrane Fusion: Mechanisms and Simulations

This lecture explores the process of vesicle fusion, detailing the steps involved such as membrane bending, merging, and rupture. It delves into the role of polyunsaturated phospholipids in lowering the energy cost of bending, the function of SNARE proteins in driving fusion pore formation, and the impact of external forces on membrane fusion. Through simulations and experimental evidence, the instructor discusses the molecular mechanisms behind vesicle fusion, the importance of specific lipid properties, and the challenges in studying the complex process. The lecture also covers the biology of Shigella infection, the clustering of STXB on membranes, and the formation of tubular invaginations. Overall, it provides insights into the biophysics of cellular processes and the interdisciplinary nature of studying membrane fusion.