Cellular Senescence and Tumor Progression

This lecture by the instructor covers the mechanisms of cellular senescence triggered by various stresses, such as oncogene activation and DNA damage response, and their role in cancer suppression signaling pathways. It explores how oncogenes induce cellular senescence, the impact of telomere dysfunction, and the correlation between telomere length and cancer risk. The lecture also delves into the essential role of telomerase in germ line cells and stem cells, the suppression of tumor formation by telomere shortening, and the implications of telomere syndromes. Various studies on telomere length and cancer risk are discussed, along with the differences in telomere biology between mice and humans.