Cancer Genomics: Comprehensive Molecular Characterization and Evolution

This lecture delves into the comprehensive genomic characterization of human cancers, focusing on glioblastoma and breast tumors. It explores the genetic alterations, pathways, and molecular portraits of these cancers, highlighting mutual exclusivity, synthetic lethal interactions, and intra-tumor heterogeneity. The study of cancer evolution, single-cell genomic analyses, tumor microenvironment, and personalized treatment design are also discussed.