BRCA2 Mutations: Mechanisms and Implications

This lecture delves into the impact of BRCA2 mutations on DNA repair mechanisms and genomic stability. It explores the role of BRCA1 and BRCA2 in maintaining genomic integrity, the effects of BRCA2 deficiency on cell sensitivity to DNA damage, and the development of therapeutic strategies for BRCA mutant cancers. The lecture also discusses the clinical management of BRCA1 and BRCA2 mutation carriers, the mechanisms of resistance in BRCA-associated cancers, and the potential of PARP inhibitors in treating these cancers.