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This lecture covers advanced methods for human neuromodulation, focusing on transcranial electric stimulation and non-invasive deep brain stimulation. Topics include electrode placement, stimulation protocols, individualized MRI for accurate current delivery, optimization techniques, and home-based self-application challenges. The instructors discuss the potential of combining neuromodulation with behavioral training and other interventions, addressing issues such as heterogeneity in response, genetic factors, and external influences. They also explore the use of high-definition electrodes, current density optimization, and the application of techniques like tACS and deep TMS for modulating brain activity.