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This lecture covers the concept of neuroplasticity, which refers to the brain's ability to change through growth, reorganization, and connection. It explores the history of neuroplasticity, from early experiments in the 18th century to modern applications. The lecture also delves into different types of brain stimulation techniques, such as transcranial electric stimulation and transcranial direct current stimulation, and their impact on deep brain regions in various neuro-psychiatric disorders. The discussion includes the use of transcranial temporal interference stimulation (tTIS) and its effects on motor sequence learning and reinforcement. The lecture highlights the potential of non-invasive brain stimulation technologies for clinical translation and their implications for conditions like stroke, depression, and dementia.