Drug Metabolism: Xenobiotics and Enzymes

This lecture covers the metabolism of drugs, focusing on xenobiotics and enzymes involved in biotransformation reactions. It explains the two phases of biotransformation, the role of metabolizing enzymes, and the tissue sources of these enzymes. The lecture also discusses the importance of drug lipophilicity in determining metabolic pathways and provides examples of oxidation reactions. Furthermore, it delves into the subcellular localization of Phase I enzymes and the properties of Phase I metabolites. The lecture concludes with insights into the factors affecting drug metabolism, such as inducers and inhibitors of drug metabolism, drug-drug interactions, and the impact of substances like grapefruit juice and alcohol on drug metabolism.