Pharmacogenetics: Drug Response and Genetic Variability

This lecture explores the field of pharmacogenetics, focusing on how an individual's genetic profile influences their response to medical treatments. It covers candidate genes involved in pharmacogenetics, such as those affecting drug metabolism and plasma protein binding. The lecture delves into the impact of genetic polymorphisms on drug metabolism enzymes, like CYP2D6, and their role in drug response variability. Additionally, it discusses the genetic aspects of drug transporters and their influence on drug uptake and excretion. The presentation also includes case studies on the effects of genetic variations in metabolizing enzymes on drug efficacy and toxicity.