This lecture covers the Michaelis-Menten enzymatic kinetics, focusing on the quasi-stationary state hypothesis, steady-state, enzyme saturation, and the derivation of reaction rates. It explains the formation of the substrate enzyme complex, the catalytic efficiency of enzymes, and the Lineweaver-Burk representation. The lecture also discusses the catalytic perfection of enzymes and provides examples of enzymes close to the diffusion-controlled limit.